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Aminopeptidase N (APN) inhibitors suppressed the invasion of ES‐2 cells. Firstly, APN inhibitors could markedly inhibited the enzyme activity of APN of ES‐2 cells (a). Then ES‐2 cells treated with different compounds were plated into Metrigel‐coated transwell chambers and photographed after 24 h (100×) (b). (c) Data shown represent the mean number of invaded cells from five different fields. *P < 0.01.
