Table 3.

Top 5 S-MultiXcan associations by APOE region

Gene	Top tissue	N tissues	P	Z score
				Min	Max	Mean	SD
Inside APOE
PVRL2	Oesophagus muscularis	17	2.64 × 10−131	− 19.28	5.78	− 4.94	6.75
APOE	Skin, sun-exposed leg	7	4.25 × 10−101	− 19.50	7.51	− 3.58	10.50
APOC1	Adrenal gland	4	4.05 × 10−92	− 19.13	5.98	− 6.24	13.43
BLOC1S3	Oesophagus muscularis	6	9.00 × 10−75	−15.63	3.48	−  1.78	7.07
APOC4	Adrenal gland	4	1.40 × 10−39	− 9.53	5.91	−  0.92	7.96
Outside APOE
SIX5	Skin, sun-exposed leg	4	1.24 × 10−37	− 6.18	10.3	− 0.41	7.40
VASP	Testis	3	5.58 × 10−28	− 11.3	2.61	− 2.29	7.82
BIN1	Oesophagus muscularis	23	3.58 × 10−16	− 6.32	4.09	− 2.21	3.26
CLU	Skin, sun-exposed leg	8	7.51 × 10−14	− 3.07	8.22	1.28	4.12
CR1	Oesophagus muscularis	7	1.69 × 10−11	− 0.38	7.33	4.299	3.45

N tissues, number of tissues with significant gene-based association; Z score, minimum, maximum, mean, and standard deviation of the Alzheimer’s disease association coefficient from S-MultiXcan