Table 5.
Biological pathways associated with Alzheimer’s disease association signals in the dorsolateral prefrontal cortex from the CMC
| Pathway ID | Pathway name | Coef | SE | P |
|---|---|---|---|---|
| GTEx S-MultiXcan | ||||
| R-HSA-8964043 | Plasma lipoprotein clearance | − 0.7861 | 0.1745 | 6.64 × 10−6 |
| CMC DLPFC | ||||
| R-HSA-168179 | Toll-like receptor TLR1:TLR2 cascade | 0.3684 | 0.0263 | 1.32 × 10−44 |
| R-HSA-167044 | Signalling to RAS | 0.6713 | 0.0493 | 2.78 × 10−42 |
| R-HSA-187687 | Signalling to ERKs | 0.5786 | 0.0438 | 6.52 × 10−40 |
| R-HSA-447115 | Interleukin-12 family signalling | 0.6109 | 0.0468 | 7.27 × 10−39 |
| R-HSA-354192 | Integrin alphaIIb beta3 signalling | 0.6337 | 0.0486 | 8.14 × 10−39 |
Coef beta coefficient from a logistic regression model testing the enrichment of genes associated with Alzheimer’s disease in Reactome pathways