Table 2.
Antimutagenic activity of furanocoumarins (11, 12, 14, and 15) against Trp-P-1 (0.04 μg/plate) using the Ames test [4]a
| Inhibition % (Based on number of revertant colonies) | |||||
|---|---|---|---|---|---|
| 3.1 nmol/plate | 6.3 nmol/plate | 12.5 nmol/plate | 25 nmol/plate | 50 nmol/plate | |
| Furanocoumarins | |||||
| 11 | 22% | 13.9% | 25.0% | 31.5% | 40.9% |
| 12 | 27.0% | 35.9% | 51.6% | 59.5% | 74.7% |
| 14 | 25.0% | 40.5% | 49.7% | 62.8% | 73.7% |
| 15 | 5.6% | 5.6% | 18.1% | 36.6% | 51.2% |
a No compound showed antibacterial activity [< 5.0% inhibition at highest concentration] against the S. typhimurium TA98 strain at the tested concentrations