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. 2020 Apr 16;21:18. doi: 10.1186/s12865-020-00349-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Radiation decreases Foxp3 expression in natural and induced human CD4 + CD25+ T_REGS. nT_REG and iT_REG cells were mock irradiated or exposed to 10Gy of ionizing radiation. a After 48 h, nT_REGS were stained for expression of CD4 and CD25 by flow cytometry. b Expression of Foxp3 was evaluated within the CD4 + CD25+ population. c 48 h after irradiation, TGF-β1-induced T_REGS were stained for expression of CD4 and CD25 by flow cytometry. d Expression of Foxp3 was evaluated within the total CD4 + CD25+ population. e iT_REGS were evaluated for the expression of Foxp3 within the CD4 + CD25^hi population. Experiment was repeated three times with similar results. Error bars represent SEM. *P ≤ 0.05 by paired, one-tailed Student t test