Table 3.
Univariable and multivariable Poisson regression analyse for Lyme disease incidence of a new diagnosis in the UK
| Univariable Analysis | Multivariable Analysis Model 1 | Multivariable Analysis Model 2 | ||||
|---|---|---|---|---|---|---|
| Independent Variable | IRR (95% CI) | p-value | IRR (95% CI) | p-value | IRR (95% CI) | p-value |
| Year (linear) | 1.05 (1.05–1.06) | < 0.001 | 1.05 (1.04–1.06) | < 0.001 | 1.04 (1.03–1.05) | < 0.001 |
| Sex | ||||||
| Male | 1 | 1 | 1 | |||
| Female | 1.08 (1.01–1.15) | 0.02 | 1.06 (0.99–1.13) | 0.08 | 1.20 (1.10–1.30) | < 0.001 |
| Age (Years) | ||||||
| < 1 | 0.04 (0.002–0.18) | 0.001 | 0.04 (0.003–0.20) | 0.002 | 0.07 (0.004–0.31) | 0.008 |
| 1–5 | 0.55 (0.42–0.69) | < 0.001 | 0.52 (0.40–0.67) | < 0.001 | 0.65 (0.48–0.88) | 0.006 |
| 6–10 | 0.76 (0.63–0.91) | < 0.001 | 0.72 (0.59–0.87) | < 0.001 | 0.95 (0.75–1.20) | 0.67 |
| 11–15 | 0.66 (0.55–0.80) | < 0.001 | 0.67 (0.55–0.81) | < 0.001 | 0.88 (0.70–1.11) | 0.29 |
| 16–20 | 0.63 (0.52–0.75) | < 0.001 | 0.64 (0.53–0.78) | < 0.001 | 0.87 (0.69–1.10) | 0.25 |
| 21–25 | 0.64 (0.54–0.77) | < 0.001 | 0.68 (0.56–0.81) | < 0.001 | 0.85 (0.68–1.07) | 0.18 |
| 26–30 | 0.78 (0.66–0.92) | 0.004 | 0.81 (0.68–0.96) | 0.02 | 0.96 (0.77–1.20) | 0.74 |
| 31–35 | 0.80 (0.68–0.94) | 0.006 | 0.85 (0.72–1.01) | 0.06 | 0.86 (0.68–1.07) | 0.17 |
| 36–40 | 0.82 (0.70–0.96) | 0.012 | 0.83 (0.70–0.98) | 0.02 | 0.89 (0.72–1.11) | 0.30 |
| 41–45 | 1 | 1 | 1 | 1 | ||
| 46–50 | 0.98 (0.85–1.14) | 0.83 | 0.97 (0.83–1.13) | 0.72 | 0.94 (0.77–1.17) | 0.60 |
| 51–55 | 0.98 (0.84–1.14) | 0.80 | 0.92 (0.79–1.08) | 0.33 | 0.92 (0.74–1.14) | 0.45 |
| 56–60 | 1.27 (1.09–1.47) | 0.002 | 1.23 (1.06–1.44) | 0.007 | 1.25 (1.02–1.53) | 0.03 |
| 61–65 | 1.25 (1.07–1.45) | 0.004 | 1.19 (1.02–1.39) | 0.03 | 1.02 (0.82–1.26) | 0.89 |
| 66–70 | 1.01 (0.86–1.20) | 0.86 | 0.99 (0.83–1.17) | 0.89 | 0.98 (0.77–1.23) | 0.84 |
| 71–75 | 0.89 (0.73–1.07) | 0.21 | 0.89 (0.73–1.07) | 0.21 | 0.85 (0.66–1.10) | 0.23 |
| 76–80 | 0.63 (0.50–0.79) | < 0.001 | 0.66 (0.52–0.83) | < 0.001 | 0.77 (0.57–1.02) | 0.07 |
| 81–85 | 0.43 (0.32–0.57) | < 0.001 | 0.46 (0.33–0.61) | < 0.001 | 0.50 (0.34–0.73) | < 0.001 |
| > 85 | 0.13 (0.08–0.20) | < 0.001 | 0.14 (0.09–0.23) | < 0.001 | 0.17 (0.09–0.29) | < 0.001 |
| Nation | ||||||
| England | 1 | 1 | N/A | |||
| Northern Ireland | 0.36 (0.27–0.47) | < 0.001 | 0.36 (0.26–0.48) | < 0.001 | N/A | |
| Scotland | 3.01 (2.82–3.22) | < 0.001 | 3.16 (2.95–4.76) | < 0.001 | N/A | |
| Wales | 0.52 (0.44–0.61) | < 0.001 | 0.56 (0.47–0.66) | < 0.001 | N/A | |
| Townsend | ||||||
| 1 | 1 | 1 | 1 | |||
| 2 | 1.29 (1.18–1.41) | < 0.001 | 1.12 (1.02–1.22) | 0.01 | 0.88 (0.79–0.99) | 0.03 |
| 3 | 0.94 (0.85–1.03) | 0.21 | 0.84 (0.76–0.92) | < 0.001 | 0.66 (0.59–0.75) | < 0.001 |
| 4 | 0.64 (0.58–0.72) | < 0.001 | 0.54 (0.49–0.61) | < 0.001 | 0.55 (0.48–0.64) | < 0.001 |
| 5 | 0.41 (0.35–0.48) | < 0.001 | 0.32 (0.28–0.37) | < 0.001 | 0.43 (0.35–0.52) | < 0.001 |
| Rural Urban | ||||||
| Urban | 1 | 1 | ||||
| Rural | 1.96 (1.78–2.15) | < 0.001 | N/A | N/A | 1.71 (1.56–1.89) | < 0.001 |
IRR Incidence rate ratio, CI Confidence Interval