Table 2.
In vivo studies of compounds that regulate autophagy in ovarian cancer
| Compounds | Effects on autophagy | Involved mechanism | Cell effects | Tumor model | References |
|---|---|---|---|---|---|
| Paeonol | Activator | Inhibiting mTOR/AKT | Protective | Xenograft (A2780 cells) | [91] |
| JS-K | Activator | Production of ROS/RNS | Cytotoxic | Xenograft (SKOV3 cells) | [92] |
| Matrine | Activator | Inhibiting mTOR/AKT | Cytotoxic | Xenograft (A2780 cells) | [93] |
| Ormeloxifene | Activator | Promoting ER stress and unfolded protein response | Cytotoxic | Xenograft (PA-1cells) | [94] |
| Phyllanthusmin | Inhibitor | Disruption of lysosomal function | Cytotoxic | Xenograft (OVCAR8-RFP cells) | [95] |
| APG-1387 | Activator | Not clear | Cytotoxic | Xenograft (SKOV3 cells) | [96] |
| Bortezomib | Inhibitor | Promotion of ERK phosphorylation to suppress cathepsin B | Cytotoxic | Xenograft (MOSEC/LUC) | [97] |