Figure 2.

Both 5hmC and 5mC are present at detectable levels in all three tissue types. (a) 5hmC and (b) 5mC detectability was determined using a Δβ threshold of 0.0799 (dashed line). (c) An average of 57.8 ± 0.3%, 7.4 ± 1.6%, and 12.5 ± 1.2% of loci contained detectable 5hmC in cerebellum, blood, and saliva, respectively. (d) Of all loci, >80% showed detectable 5mC in all three tissue types, with an average of 81.3 ± 1.1%, 85.1 ± 0.3%, and 85.5 ± 1.5% in cerebellum, blood, and saliva, respectively. Data from (c) and (d) include ‘all probes’ regardless of annotation or genomic location.