Figure 3.

The EPIC array contains an equal distribution of probes with detectable 5hmC and 5mC across chromosomes. (a) Although the fraction of probes containing 5hmC in blood and saliva is greatly reduced, all three tissue types show an equal distribution across autosomes. Of particular importance, in cerebellum, >50% of all probes on autosomes show detectable 5hmC, with the exception of chromosome 19, at>48%. Detectability is reduced on sex chromosomes, primarily chromosome Y. (b) Also with the exception of chromosome 19, 5mC is detectable at >75% of probes on all chromosomes in all three tissue types, including chrX and chrY.