Table 2.
Targeted gene alterations and drugs of the included studies for the meta analyses
| Study | Targeted gene alteration | Detailed genotypes | Targeted drugs |
|---|---|---|---|
| CLCGP | EGFR mutations | Not shown | gefitinib, erlotinib |
| Molina-Vila | EGFR mutations | Not shown | erlotinib |
| Bria E | EGFR mutation |
Exon 19 deletion; Exon 21 L858R mutation |
gefitinib |
| Canale M | EGFR mutation |
Exon 19 deletion Exon 21 L858R mutations Exon 21 L861Q mutations Exon 18 mutations |
gefitinib, erlotinib, afatinib, dacomitinib |
| Labbé C | EGFR mutation |
Exon 19 deletion Exon 21 L858R mutation Exon 18 mutations, Exon 19 insertion, Exon 19 L747P mutation Multiple mutations (Exons 21 + 20, exons 19 + 20, exons 21 + 18) |
gefitinib, erlotinib |
| Vander Laan | EGFR mutation |
Exon 19 deletions Exon 21 L858R mutation Exon 18 G719X mutation Exon 20 insertions Exon 20 S768I mutation |
gefitinib, erlotinib, afatinib |
| Aisner | EGFR mutation |
Exon 19 deletions Exon 21 L858R mutation Exon 18 G719X mutation Exon 21 L861Q mutation |
EGFR-TKIs |
| Tsui DWY | EGFR mutation | EGFR Exon 21 L858R mutations | gefitinib |
| HelenaA.Yu | EGFR mutation |
EGFR T790M mutation Exon 19 deletion Exon21 L858R mutation Exon 20 insertions Exon 18 deletion Exon 19 insertion Exon21 L861Q mutation Exon 18 G719X mutation Exon 19 L747P. mutation Exon 18 E709X mutation + Exon 18 G719X mutation Exon 18 G719X+ Exon 20 S768I mutation Exon 18 G719X+ Exon21 L861Q mutation |
erlotinib |
| Youjin Kim | EGFR mutation |
Exon21 L861Q mutation Exon 19 deletion Exon21 L858R mutation Exon18 G719A mutation Exon21 L833V mutation + Exon21 L858R mutation Exon21 L833V+ Exon21 H835L mutation |
gefitinib, erlotinib, afatinib, osimertinib, olmutinib |
| Rachiglio AM | EGFR mutation |
Exon 19 deletion Exon21 L858R Exon20 T790M |
gefitinib, erlotinib, afatinib, |
| Kron A | ALK re-arrangements | EML4-ALK fusions |
crizotinib, ceritinib, alectinib, brigatinib |
| Yu Y | ALK re-arrangements |
EML4-ALK fusions Non-EML4-ALK fusions |
crizotinib |
| Christopoulos P | ALK re-arrangements |
EML4-ALK fusions KIF5B-ALK fusions |
ALK-TKIs |
| Song P | ALK re-arrangements |
EML4-ALK fusions Non-EML4-ALK fusions |
ALK-TKIs |
Abbreviations: EGFR Epidermal growth factor receptor, ALK Anaplastic lymphoma kinase, TKI Tyrosine kinase inhibitor