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Summary of Efficacy of Single Agent Checkpoint Inhibitors
| Trial/Monotherapy | Prior Treatment | N | ORR (95% CI) | PFS months (95% CI) | OS months (95% CI) |
|---|---|---|---|---|---|
| CheckMate-025 Nivolumab13 |
1–2 anti-angiogenesis agents | 821 | 25% | 4.6 (3.7–5.4) | 25.0 (21.8− not estimable) |
| KEYNOTE-427 Cohort A Pembrolizumab14 |
Therapy-naïve | 110 | 36.4% (27.4–46.1) | 7.1 (5.6–11.0) | Not reached |
| IMmotion150 Atezolizumab19 |
Therapy-naive | 103 | 25% (17–35) | 6.1 (5.4–13.6) | Not reported |
