Table 4.
CDKN2A copy number by FISH and clinical information for patients with chordoma
| CDKN2A (FISH) | Disomic (%) | Copy number loss (%) | Copy number gain (%) | P value | q value | |
|---|---|---|---|---|---|---|
| Age | <40 | 15/22 (68) | 6/22 (27) | 1/22 (5) | ||
| >40 | 44/113 (39) | 58/113 (51) | 11/113 (10) | 0.0204 | 0.1020 | |
| Stage of tumour | Primary | 86/193 (44) | 88/193 (46) | 19/193 (10) | ||
| LR1–LR5 | 19/70 (27) | 43/70 (61) | 8/70 (12) | 0.0480 | 0.1542 | |
| Anatomical site | Metastasis | 2/11 (18) | 7/11 (64) | 2/11 (18) | 0.2253 | 0.3417 |
| Sacrum‐coccyx | 36/93 (37) | 47/93(52) | 10/93 (11) | |||
| Mobile spine | 14/25 (56) | 10/25 (40) | 1/25 (4) | 0.2392 | 0.3417 | |
| Skull base | 28/56 (50) | 21/56 (37) | 7/56 (13) | 0.3342 | 0.4177 | |
Results were available for both p16/CDKN2A IHC and FISH for at least one sample from 243 of 320 patients.