Table 5.
Drug interactions with chloroquine and hydroxychloroquine (“Red List” 2010).
| No effect | CQ/HCQ reduce bioavailability of | Bioavailability of CQ/HCQ reduced by | Bioavailability of CQ/HCQ enhanced by | CQ/HCQ increase the risk of side effects of | CQ/HCQ increase plasma levels of | Diminished effect of | Increased rate of skin reactions | Increased rate of muscle weakness | |
|---|---|---|---|---|---|---|---|---|---|
| Acetylsalicylic acid | + | ||||||||
| Aminoglycosides | + | ||||||||
| Ammonium chloride | |||||||||
| Ampicillin | + | ||||||||
| Aurothioglucose | + | ||||||||
| Kaolin/pectin | + | ||||||||
| Cholestyramine | + | ||||||||
| Cimetidine | + | ||||||||
| Cyclosporine A | + | ||||||||
| Digoxin | + | ||||||||
| Corticosteroids | + | ||||||||
| Imipramine | + | ||||||||
| Methotrexate | + | ||||||||
| Neostigmine | + | ||||||||
| Penicillamine | + | ||||||||
| Phenylbutazone | + | ||||||||
| Physostigmine | + | ||||||||
| Pyrimethamine/sulfadoxine | + | ||||||||
| Quinacrine | + | ||||||||
| Rabies vaccination | + | ||||||||
| Ranitidine | + | ||||||||
| Ritonavir | + | ||||||||
| Typhus vaccination | + |