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. 2020 Apr 10;368(6492):779–782. doi: 10.1126/science.abb7498

Fig. 2. Structure of N-terminal NiRAN domain and β hairpin.

Fig. 2

(A) Overall structure of the N-terminal NiRAN domain and β hairpin of COVID-19 virus nsp12. The N-terminal NiRAN domain and β hairpin of COVID-19 virus nsp12 are shown as yellow and cyan cartoons, respectively, whereas the other regions of COVID-19 virus nsp12 are shown as a molecular surface with the same color scheme used in Fig. 1. The NiRAN domain of SARS-CoV nsp12 is superimposed to its counterpart in COVID-19 virus nsp12 and is shown in purple. (B) Key interactions between the β hairpin and other domains. The β hairpin is shown as a cyan tube with its key residues in stick mode. These have the closest contacts with other domains of COVID-19 virus nsp12. The interacting residues in the palm and fingers subdomain of the RdRp domain and the NiRAN domain are identified by the labels. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.