TABLE 4.
90% confidence interval (CI) ratios of natural logarithm‐transformed pharmacokinetic parameters of calcium glucoheptonate (test drug)/calcium carbonate (reference drug)
| Parameter | Geometric mean ratio – % | 90% CIs of the geometric mean ratio (%) | Intra‐subject coefficient of variation (%) | |||
|---|---|---|---|---|---|---|
| 6 hours | 12 hours | 6 hours | 12 hours | 6 hours | 12 hours | |
| C max, mg/L | 99.23 | 96.30 | 78.88‐124.83 | 77.09‐120.31 | 45.19 | 44.90 |
| AUC0– t, mg*h/L | 91.20 | 86.07 | 66.42‐125.22 | 60.58‐122.30 | 62.43 | 70.86 |
Abbreviations: AUC0– t, area under the plasma concentration‐time curve; C max, maximum plasma concentration.