Figure 2.

IL‐6 expression was induced predominantly by the stimulation of β2AR, not β3AR. A ‐ C) CFs were treated with the indicated concentrations of ISO (A), SAL (B), or CL‐316243 (C) for 1 h. The expression of IL‐6, IL‐1β, and TNF‐α mRNA was measured by real‐time RT‐PCR. Results are shown as mean ± SEM (A, n = 8, B, C, n = 6). *P < .05, **P < .01 vs vehicle by Dunnett test. D, CFs were treated with the indicated concentrations of SAL for 24 h. IL‐6 protein, secreted by CFs in culture medium, was measured by ELISA. Results are shown as mean ± SEM (n = 6). *P < .05, **P < .01 vs vehicle by Dunnett test