Table 4a.
Changes in Adipose and Lean Indices Between the Aramchol- Versus Placebo-Treated Patients on DXA
| Aramchol (n=20) | Placebo (n=15) | Difference | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Posttreatment | P-Value | Baseline | Posttreatment | P-Value | P-Value | |
| Adipose Indices | |||||||
| Total Body % Fat | 31.4 (9.2) | 31.8 (9.4) | 0.4121 | 31.8 (7.0) | 32.4 (7.7) | 0.3029 | 0.5687 |
| Fat Mass/Height2 (kg/m2) | 9.8 (4.9) | 10.1 (4.5) | 0.3577 | 8.4 (3.4) | 9.3 (2.7) | 0.6097 | 0.9751 |
| Android/Gynoid Ratio | 1.4 (0.3) | 1.3 (0.2) | 0.2794 | 1.4 (0.7) | 1.4 (0.8) | 0.7609 | 0.1349 |
| % Fat Trunk/% Fat Legs | 1.3 (0.3) | 1.3 (0.2) | 0.4918 | 1.6 (0.9) | 1.4 (0.7) | 0.0007 | 0.1948 |
| Trunk/Limb Fat Mass Ratio | 1.6 (0.4) | 1.6 (0.4) | 0.5706 | 2.0 (0.8) | 1.8 (0.8) | 0.0317 | 0.7873 |
| Est. VAT Mass (g) | 957 (501) | 982 (537) | 0.8983 | 971 (408) | 996 (543) | 0.1070 | 0.2619 |
| Est. VAT Volume (cm3) | 1034 (541) | 1061 (583) | 0.8983 | 1050 (441) | 1076 (588) | 0.1070 | 0.2637 |
| Est. VAT Area (cm2) | 198 (104) | 204 (112) | 0.8909 | 201 (85) | 207 (112) | 0.1037 | 0.2626 |
| Lean Indices | |||||||
| Lean/Height2 (kg/m2) | 19.9 (3.3) | 19.8 (2.7) | 0.9317 | 19.4 (2.2) | 19.0 (3.5) | 0.0276 | 0.2608 |
| Appen. Lean/Height2 (kg/m2) | 8.8 (2.0) | 8.7 (1.6) | 0.5705 | 8.1 (1.4) | 7.9 (1.9) | 0.0145 | 0.1939 |
Data are expressed as median (IQR) with p-values from Wilcoxon signed rank test or mean difference with P-value from t-test in parentheses. P-values in bold denote statistical significance < 0.05.