Table 2. Univariate and multivariate overall survival analyses of clinicopathological covariates in CRC patients.

Feature	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P
Gender		0.885
Male	1
Female	0.970 [0.637–1.475]
Age (Year)		0.161
≤65	1
>65	1.338 [0.891–2.011]
pT stage		0.002		0.039
T1–2	1		1
T3–4	2.230 [1.347–3.693]		1.761 [1.029–3.014]
pN stage		<0.001		<0.001
N0	1		1
N1	1.788 [1.084–2.949]		1.589 [0.943–2.676]
N2	5.524 [3.391–8.998]		3.995 [2.304–6.927]
Metastasis		<0.001		0.001
No	1		1
Yes	4.078 [1.964–8.467]		3.509 [1.624–7.582]
Tumor location		0.419
Left side	1
Right side	1.208 [0.764–1.911]
Perineural/vascular invasion		0.005		0.179
No	1		1
Yes	1.960 [1.223–3.141]		1.418 [0.852–2.358]
Pathological type		0.697
Protrude type	1
Infiltrating type	1.354 [0.634–2.894]
Ulcerative type	1.234 [0.705–2.162]
Differentiation		0.019		0.257
Poor	1		1
Medium/high	0.523 [0.305–0.898]		1.427 [0.772–2.639]
Postoperative chemoradiotherapy		0.786
No	1
Yes	1.058 [0.704–1.591]
CA199		0.060
Normal	1
High	1.790 [0.976–3.283]
CA724		<0.001		0.001
Normal	1		1
High	2.271 [1.450–3.557]		2.261 [1.379–3.708]
CA242		0.149
Normal	1
High	1.520 [0.861–2.685]
CA125		0.058
Normal	1
High	1.945 [0.977–3.868]

Note:

CEA, carcinoembryonic antigen; CRC, colorectal cancer; pT stage, pathological tumor stage; pN stage, pathological node stage.