Table 3. Univariate and multivariate disease-free survival analyses of clinicopathological covariates in CRC patients.
| Feature | Disease-free survival | |||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | P | HR (95% CI) | P | |||
| Gender | 0.898 | |||||
| Male | 1 | |||||
| Female | 0.974 [0.645–1.469] | |||||
| Age (Year) | 0.403 | |||||
| ≤65 | 1 | |||||
| >65 | 1.186 [0.795–1.770] | |||||
| pT stage | 0.001 | 0.036 | ||||
| T1–2 | 1 | 1 | ||||
| T3–4 | 2.244 [1.371–3.675] | 1.751 [1.038–2.956] | ||||
| pN stage | <0.001 | <0.001 | ||||
| N0 | 1 | 1 | ||||
| N1 | 1.944 [1.195–3.161] | 1.714 [1.031–2.849] | ||||
| N2 | 5.462 [3.361–8.874] | 3.820 [2.192–6.660] | ||||
| Metastasis | <0.001 | 0.003 | ||||
| No | 1 | 1 | ||||
| Yes | 4.629 [2.231–9.604] | 3.292 [1.514–7.154] | ||||
| Tumor location | 0.245 | |||||
| Left side | 1 | |||||
| Right side | 1.302 [0.835–2.033] | |||||
| Perineural/vascular invasion | 0.009 | 0.285 | ||||
| No | 1 | 1 | ||||
| Yes | 1.874 [1.172–2.996] | 1.316 [0.795–2.178] | ||||
| Pathological type | 0.793 | |||||
| Protrude type | 1 | |||||
| Infiltrating type | 1.256 [0.594–2.655] | |||||
| Ulcerative type | 1.187 [0.688–2.046] | |||||
| Differentiation | 0.023 | 0.294 | ||||
| Poor | 1 | 1 | ||||
| Medium/high | 0.536 [0.313–0.918] | 1.383 [0.754–2.536] | ||||
| Postoperative chemoradiotherapy | 0.706 | |||||
| No | 1 | |||||
| Yes | 1.080 [0.723–1.614] | |||||
| CA199 | 0.069 | |||||
| Normal | 1 | |||||
| High | 1.753 [0.957–3.210] | |||||
| CA724 | 0.001 | 0.005 | ||||
| Normal | 1 | 1 | ||||
| High | 2.097 [1.342–3.275] | 2.028 [1.238–3.320] | ||||
| CA242 | 0.070 | |||||
| Normal | 1 | |||||
| High | 1.664 [0.959–2.889] | |||||
| CA125 | 0.066 | |||||
| Normal | 1 | |||||
| High | 1.906 [0.959–3.787] | |||||
Note:
CEA, carcinoembryonic antigen; CRC, colorectal cancer; pT stage, pathological tumor stage; pN stage, pathological node stage.