. 2020 Apr 14;8:e8670. doi: 10.7717/peerj.8670

Table 3. KEGG pathway analysis of upregulated and downregulated genes in MB.

Database	ID	Term	Gene Count	P-Value	Gene names
Up-regulated
KEGG PATHWAY	hsa04110	Cell cycle	4	2.28E–06	TTK, CDC20, MCM7, CDK6
KEGG PATHWAY	hsa04120	Ubiquitin mediated proteolysis	2	0.004624353	CDC20, UBE2C
KEGG PATHWAY	hsa05203	Viral carcinogenesis	2	0.009970546	CDC20, CDK6
KEGG PATHWAY	hsa00670	One carbon pool by folate	1	0.015198488	TYMS
KEGG PATHWAY	hsa05206	MicroRNAs in cancer	2	0.020243092	CDK6, SOX4
KEGG PATHWAY	hsa03030	DNA replication	1	0.026628344	MCM7
KEGG PATHWAY	hsa03022	Basal transcription factors	1	0.033001239	GTF2IRD1
KEGG PATHWAY	hsa00330	Arginine and proline metabolism	1	0.03652431	ODC1
KEGG PATHWAY	hsa00480	Glutathione metabolism	1	0.037930065	ODC1
KEGG PATHWAY	hsa05223	Non-small cell lung cancer	1	0.040735637	CDK6
Down-regulated
KEGG PATHWAY	hsa04721	Synaptic vesicle cycle	4	8.12E–06	DNM3, UNC13C, DNM1, VAMP2
KEGG PATHWAY	hsa05100	Bacterial invasion of epithelial cells	3	0.000492126	DNM3, DNM1, ELMO1
KEGG PATHWAY	hsa04911	Insulin secretion	3	0.000627009	RAPGEF4, CAMK2B, VAMP2
KEGG PATHWAY	hsa04066	HIF-1 signaling pathway	3	0.001075892	HK1, TF, CAMK2B
KEGG PATHWAY	hsa04072	Phospholipase D signaling pathway	3	0.002737401	DNM3, RAPGEF4, DNM1
KEGG PATHWAY	hsa04514	Cell adhesion molecules (CAMs)	3	0.002843803	NRXN2, CNTN2, CNTNAP1
KEGG PATHWAY	hsa04961	Endocrine and other Factor-regulated calcium reabsorption	2	0.003884233	DNM3, DNM1
KEGG PATHWAY	hsa00524	Butirosin and neomycin biosynthesis	1	0.011244262	HK1
KEGG PATHWAY	hsa04144	Endocytosis	3	0.01354801	DNM3, DNM1, SH3GL2
KEGG PATHWAY	hsa04070	Phosphatidylinositol signaling system	2	0.0153706	CDS1, TMEM55A

Notes.

Abbreviation