Table 3.

Regression-Adjusted and Inverse Probability of Treatment Weight (IPTW) Adjusted Cox Proportional Hazard Regression Results for Incident and Persistent Major Mobility Disability (MMD) and Injurious Falls

	MMD	Persistent MMD	Injurious falls
	HR (95% CI)	HR (95% CI)	HR (95% CI)
Individual intervention and exposure regression terms. Controlled for all baseline characteristics
PA versus HE intervention	0.74 (0.58–0.95)	0.58 (0.42–0.81)	0.75 (0.49–1.16)
ARB versus ACEi	0.80 (0.61–1.04)	0.73 (0.51–1.04)	1.06 (0.66–1.70)
Trial intervention versus control stratified by medication use. Controlled for all baseline characteristics
PA versus HE (ACEi users only)	0.79 (0.58–1.07)	0.64 (0.43–0.95)	0.70 (0.41–1.19)
PA versus HE (ARB users only)	0.67 (0.44–1.02)	0.48 (0.26–0.87)	0.87 (0.42–1.79)
IPTW-adjusted models
Direct medication group comparison—pooled analytic cohort
ARB versus ACEi	0.72 (0.60–0.85)	0.65 (0.52–0.82)	1.05 (0.78–1.41)

Note: p-value for interaction between intervention and medications was not significant in all models. Medication comparisons were similar magnitude for PA and HE interventions when analyzed separately in IPTW models. Post hoc power calculations for pooled survival analysis: MMD (0.94); persistent MMD (0.96); and falls (0.81). ACEi = angiotensin-converting enzyme inhibitors; ARB = angiotensin receptor blockers; HR = hazard ratio; MMD = major mobility disability; 95% CI = 95% confidence interval.