Table 1.
NanoString Analysis of Inflammation-Related Genes
| Gene | 18-mo f/f (n = 2) | 18-mo KO (n = 3) | 18-mo KO/fl | Gene | 7-mo f/f (n = 3) | 7-mo KO (n = 3) | 18-mo KO/fl |
|---|---|---|---|---|---|---|---|
| Ifit2 | 5,377.12 | 164.07 | 0.03 | Ifit2 | 92.45 | 46.32 | 0.68 |
| Ifit3 | 5,010.93 | 90.78 | 0.02 | Ifit3 | 45.40 | 22.71 | 0.15 |
| Ifi44 | 2,474.89 | 73.77 | 0.03 | Ifi44 | 25.90 | 12.99 | 0.36 |
| Ifi27l2a | 13,168.93 | 1,757.98 | 0.13 | Ifi27l2a | 879.06 | 439.60 | 0.54 |
| Oas2 | 701.86 | 51.72 | 0.07 | Oas2 | 20.40 | 10.32 | 0.69 |
| Iigp1 | 2,780.77 | 226.05 | 0.08 | Iigp1 | 82.05 | 41.04 | 0.34 |
| Oas1a | 4,901.52 | 795.96 | 0.16 | Oas1a | 237.44 | 118.81 | 0.58 |
| Mx1 | 947.32 | 184.71 | 0.19 | Mx1 | 72.63 | 36.39 | 0.57 |
| C3 | 992.97 | 145.11 | 0.15 | Irf7 | 113.07 | 56.57 | 0.44 |
| Stat1 | 8,184.33 | 1,157.42 | 0.14 | Cxcr4 | 61.13 | 30.68 | 0.68 |
| Stat2 | 2567.22 | 474.70 | 0.18 | H2-Eb1 | 32.72 | 16.40 | 0.43 |
| Ltb4r1 | 168.95 | 40.56 | 0.24 | Chi3l3 | 36.90 | 18.46 | 0.30 |
| Ptgs1 | 533.75 | 122.02 | 0.23 | Ptgs1 | 398.06 | 199.11 | 0.57 |
| Ccl5 | 813.31 | 65.37 | 0.08 | Ccl4 | 519.72 | 259.99 | 0.73 |
| Ccr1 | 4,056.88 | 1,039.19 | 0.26 | Cd4 | 578.78 | 289.46 | 0.56 |
Notes: RNA samples were isolated from marrow cell cultures of 7- and 18-mo-old male mice and analyzed. Listed are the top 15 most downregulated genes.