Table 1.
Lipoprotein Main Parameters, Particle Number, and Main Fractions
| Young N = 12 |
Old N = 12 |
Old n-3 N = 12 |
Young vs Old | Old n-3 vs Old | |||
|---|---|---|---|---|---|---|---|
| Ratio | Adj p | Ratio | Adj p | ||||
| Main Parameters | |||||||
| Triglycerides | 85.5 ± 8 | 88.0 ± 6.4 | 72.7 ± 4.8 | 0.97 | .668 | 0.83 | .774 |
| Cholesterol | 176 ± 9 | 192 ± 9 | 190 ± 10 | 0.92 | .902 | 0.99 | .002 |
| LDL Cholesterol | 97.9 ± 7.7 | 104 ± 7 | 105 ± 8 | 0.94 | .866 | 1.01 | .842 |
| HDL Cholesterol | 54 ± 4 | 58.5 ± 2.7 | 64.5 ± 3.6 | 0.92 | .720 | 1.10 | .041 |
| Apo-A1 | 136 ± 6 | 143 ± 4 | 141 ± 5 | 0.95 | .759 | 0.99 | .513 |
| Apo-A2 | 31.6 ± 1.8 | 27.6 ± 0.7 | 24.5 ± 0.8 | 1.14 | .403 | 0.89 | .003 |
| Apo-B100 | 70.8 ± 3.8 | 80.7 ± 4.6 | 80.1 ± 4.8 | 0.88 | .457 | 0.99 | .825 |
| Particle Number | |||||||
| Apo-B | 1290 ± 70 | 1467 ± 83.3 | 1457 ± 87 | 0.88 | .457 | 0.99 | .825 |
| VLDL | 112 ± 14 | 120 ± 12 | 96.2 ± 9.4 | 0.93 | .882 | 0.80 | .009 |
| IDL | 58.3 ± 7.7 | 64.0 ± 10.4 | 56.7 ± 9.0 | 0.91 | .882 | 0.89 | .312 |
| LDL | 1094 ± 71 | 1240 ± 75.4 | 1256 ± 84.7 | 0.88 | .591 | 1.01 | .757 |
| LDL-1 | 230 ± 12 | 283 ± 21 | 266 ± 26 | 0.81 | .403 | 0.94 | .186 |
| LDL-2 | 203 ± 20 | 209 ± 18 | 192 ± 18 | 0.97 | .909 | 0.92 | .312 |
| LDL-3 | 186 ± 19 | 179 ± 20 | 164 ± 16 | 1.04 | .906 | 0.92 | .264 |
| LDL-4 | 161 ± 19 | 135 ± 19 | 115 ± 20 | 1.19 | .759 | 0.85 | .264 |
| LDL-5 | 117 ± 11 | 121 ± 16 | 142 ± 21 | 0.97 | .909 | 1.17 | .249 |
| LDL-6 | 179 ± 13 | 259 ± 15 | 319 ± 20 | 0.69 | .029 | 1.23 | .017 |
| Lipoprotein Main Fractions | |||||||
| Triglycerides, VLDL | 47.9 ± 5.6 | 43.0 ± 4.4 | 34.6 ± 2.9 | 1.11 | .830 | 0.80 | .009 |
| Triglycerides, IDL | 6.41 ± 1.03 | 6.31 ± 0.87 | 3.17 ± 0.65 | 1.02 | .950 | 0.50 | <.001 |
| Triglycerides, LDL | 13.6 ± 1.3 | 17.0 ± 1.5 | 19.1 ± 1.4 | 0.80 | .444 | 1.12 | .020 |
| Triglycerides, HDL | 8.74 ± 1.08 | 9.88 ± 1.02 | 10.6 ± 1.1 | 0.88 | .806 | 1.07 | .129 |
| Cholesterol, VLDL | 13.9 ± 1.6 | 13.6 ± 1.5 | 9.54 ± 1.30 | 1.02 | .930 | 0.70 | .002 |
| Cholesterol, IDL | 6.65 ± 0.96 | 7.20 ± 1.46 | 6.01 ± 1.20 | 0.92 | .902 | 0.83 | .264 |
| Cholesterol, LDL | 97.9 ± 7.7 | 104 ± 7 | 105 ± 8 | 0.94 | .866 | 1.01 | .842 |
| Cholesterol, HDL | 53.5 ± 3.5 | 58.5 ± 2.7 | 64.5 ± 3.6 | 0.91 | .720 | 1.10 | .041 |
| Free Cholesterol, VLDL | 6.28 ± 0.71 | 6.75 ± 0.66 | 5.16 ± 0.53 | 0.93 | .882 | 0.76 | .003 |
| Free Cholesterol, IDL | 2.19 ± 0.30 | 2.25 ± 0.42 | 1.60 ± 0.34 | 0.97 | .934 | 0.71 | .051 |
| Free Cholesterol, LDL | 26.9 ± 2.1 | 29.4 ± 2.0 | 29.9 ± 2.0 | 0.91 | .806 | 1.02 | .637 |
| Free Cholesterol, HDL | 10.2 ± 0.8 | 12.1 ± 0.8 | 15.0 ± 0.9 | 0.84 | .457 | 1.24 | .002 |
| Phospholipids, VLDL | 14.5 ± 1.6 | 13.7 ± 1.3 | 11.1 ± 1.0 | 1.06 | .882 | 0.81 | .016 |
| Phospholipids, IDL | 4.42 ± 0.36 | 4.28 ± 0.53 | 3.58 ± 0.56 | 1.03 | .909 | 0.84 | .076 |
| Phospholipids, LDL | 57.2 ± 3.6 | 61.2 ± 3.7 | 61.0 ± 3.9 | 0.93 | .806 | 1.00 | .928 |
| Phospholipids, HDL | 79.5 ± 4.3 | 83.4 ± 3.8 | 85 ± 4.6 | 0.95 | .830 | 1.02 | .513 |
| Apo-A1, HDL | 137 ± 6 | 143 ± 5 | 142 ± 6 | 0.96 | .806 | 0.99 | .788 |
| Apo-A2, HDL | 32.0 ± 1.7 | 28.4 ± 0.6 | 25.5 ± 0.7 | 1.13 | .435 | 0.90 | .003 |
| Apo-B, VLDL | 6.2 ± 0.8 | 6.6 ± 0.6 | 5.3 ± 0.5 | 0.94 | .882 | 0.80 | .009 |
| Apo-B, IDL | 3.21 ± 0.42 | 3.52 ± 0.57 | 3.12 ± 0.50 | 0.91 | .882 | 0.89 | .312 |
| Apo-B, LDL | 60.2 ± 3.9 | 68.2 ± 4.1 | 69.1 ± 4.7 | 0.88 | .591 | 1.01 | .757 |
Note: Data are shown as mean ± SEM with p-values adjusted for multiple comparisons using the Benjamini–Hochberg Adjustment. HDL = High-density lipoprotein; LDL = Low-density lipoprotein; VLDL = Very low-density lipoprotein.