Table 4.
Associations between plasma ET-1 levels and blood and plasma factors.
| ET-1 | |||
|---|---|---|---|
| Blood and Plasma Factors | β | p-value | 95% Confidence Interval |
| Albumin (g/dL) | 0.035 | 0.006* | 0.011, 0.060 |
| Non albumin Protein (g/dL) | −0.016 | 0.450 | −0.059, 0.027 |
| Fibrinogen (mg/dL) | −0.022 | 0.358 | −0.094, 0.050 |
| hsCRP (mg/L) | 0.260 | 0.118 | −0.068, 0.588 |
| Interleukin-1β (pg/mL) | 0.082 | 0.012* | 0.019, 0.146 |
| Interleukin-6 (pg/mL) | 0.135 | 0.243 | −0.096, 0.366 |
| LDL (mg/dL) | 0.006 | 0.430 | −0.010, 0.023 |
| PLAs (% total of CD41+/45+ cells) | 0.170 | 0.068 | −0.013, 0.352 |
| PF-4 (pg/mL)& | −0.148 | 0.003* | −0.238, −0.059 |
| RBCs (x106 cells/μL) | −0.002 | 0.653 | −0.011, 0.007 |
| SDF-1 (pg/mL) | 0.021 | 0.131 | −0.007, 0.049 |
| Serum Amyloid A (μg/mL) | 0.075 | 0.573 | −0.190, 0.340 |
| Total Plasma Protein (g/dL) | 0.018 | 0.243 | −0.013, 0.048 |
| Triglycerides (mg/dL) | −0.095 | 0.041* | −0.185, −0.004 |
| VEGF (pg/mL) & | −0.032 | 0.482 | −0.127, 0.062 |
| WBCs (x103 cells/μL) | −0.009 | 0.613 | −0.044, 0.026 |
Notes: Log-transformed outcomes were regressed on ET-1. Values for PF-4 and for VEGF given for participants 1–8 only.
*:
significance at P <0.05 level,
†:
significance at 0.05 <P < 0.10 level.
Abbr: ET-1, endothelin-1; hsCRP: high-sensitivity C-reactive protein; LDL: low density lipoprotein; PF-4: platelet factor 4; PLAs: platelet-leukocyte aggregates; RBC: red blood cell; SDF-1: stromal cell-derived factor-1; VEGF: vascular endothelial growth factor; WBC: white blood cell.