Table 1. Summary of the characteristics of the four herpesviruses identified in leporids.

Type	Subfamily		Common Name	Host	Physiopathology	Isolation
LeHV-1	γ	Not attributeda	Cottontail herpesvirus	Sylvilagus floridanus		Isolated from primary kidney cells cultures of Sylvilagus floridanus [13].
						No report of disease in domestic rabbits, since Oryctolagus cuniculus is not infected [10].
LeHV-2	γ	Not attributeda	Herpesvirus cuniculi	Oryctolagus cuniculus	Some evidences of a subclinical encephalitis in infected New Zealand white rabbits [30].	Isolated in 1968 from kidneys of apparently healthy Sylvilagus floridanus [31].
						Oryctolagus cuniculus is the natural host where infection is asymptomatic[32]
LeHV-3	γ	Not attributeda	Herpesvirus sylvilagus	Sylvilagus floridanus	Lymphoproliferative disease and tumour-like lesions in the lymph nodes, kidney, spleen, and liver [31,33].	Isolated from primary kidney cells cultures of Sylvilagus floridanus [13].
						Oryctolagus cuniculus is not infected
						Not isolated in WI-38, HeLa, Chang’s conjunctiva, human amnion (FL), green monkey kidney (Vero), primary rhesus monkey kidney, primary hamster kidney, BHK-21, primary mouse embryo, and primary chick embryo [33]. Isolated in DRK-3 cells [33].
						CPE appear after 10–15 days of inoculation. Infected cells show focal areas of round and distorted cells, and in 1–2 days, emerged syncytial masses containing 50 or more nuclei [31].
						H&E coloration show typical type A intranuclear inclusions in the infected cells. Complete cell destruction occurred after a 5 to 7-days period [31].
LeHV-4	α	Attributedb		Oryctolagus cuniculus	Lethargy, anorexia, conjunctivitis, fever, and abortion. Haemorrhagic dermatitis, splenic necrosis, hepatic necrosis, and multifocal pulmonary haemorrhage and oedema. Distinctive glassy eosinophilic herpetic intranuclear inclusion bodies were observed in the skin fibroblasts? And mesenchymal cells of the spleen and lung [9,34].	Isolated in rabbit skin (RS), RK13 and Vero cells [9]. CPE characterized by syncytium formation, cell enlargement, and cell lysis, similar to human herpesvirus type 1 (HHV-1). Jin et al. [9] verified that in rabbits inoculated with LHV-4, the appendix, sciatic nerve, kidney, adrenal gland, and many other organs were positive for the virus at the 5-days post infection(dpi), while at the 14 dpi only trigeminal ganglia eye and tonsil were positive.
LeHV-5	γ	Not attributed	Iberian hare herpesvirus	Lepus granatensis	Described in the results of this work

^aNot attributed by the ICTV; Viruses which may be members of the genus Rhadinovirus [35] but have not been approved as species

^bLeporid alphaherpesvirus //Leporid Herpesvirus 4