Table 3.
Nitric oxide-release properties for NO-releasing electrospun fibers in PBS (pH 7.4, 37 °C)a
| [Dendrimer]b (mg/mL) |
[NO]maxc (pmol/cm2) |
tmaxd (min) |
t[NO]e (nmol/cm2) |
t[NO]2hf (nmol/cm2) |
t1/2g (min) |
tdh (h) |
|
|---|---|---|---|---|---|---|---|
| SG 80A/HP 93A-G4 octyl/NO | 15 | 21.8 ± 5.7 | 6.1 ± 2.9 | 44.6 ± 11.1 | 43.7 ± 10.2 | 22.4 ± 3.3 | 2.2 ± 0.3 |
| SG 80A/HP 93A-G4 octyl/NO | 25 | 27.6 ± 11.7 | 6.2 ± 2.2 | 87.2 ± 19.1 | 71.2 ± 17.3 | 35.7 ± 3.9 | 4.2 ± 0.8 |
| TP 470/SG 80A-G4 octyl/NO | 25 | 14.0 ± 2.1 | 3.3 ± 0.6 | 46.7 ± 9.5 | 38.3 ± 7.2 | 47.8 ± 6.9 | 3.6 ± 0.5 |
| TP 470/HP 93A-G4 octyl/NO | 25 | 17.2 ± 6.2 | 4.0 ± 1.6 | 44.3 ± 10.1 | 39.9 ± 9.1 | 39.0 ± 4.5 | 2.9 ± 0.4 |
| TP 470/HP 93A-G4 octylQA/NO | 25 | 10.6 ± 1.5 | 4.3 ± 0.6 | 66.5 ± 16.5 | 36.2 ± 5.6 | 102.4 ± 24.6 | 6.8 ± 1.5 |
a
For all measurements, n ≥ 3 pooled experiments.
b
Dendrimer concentration in the original polymer solution.
c
Maximum flux of NO release.
d
Time required to reach maximum flux.
e
Total NO payload released per surface area.
f
NO payload released after 2 h.
g
NO release half-life.
h
Duration of NO release.