Table 2.
Nitric oxide-release properties of DPPC liposomes as a function of NO donor in PBS (pH 7.4) at 37 °C.
| NO donor | t1/2a (h) | tdb (h) | [NO]totalc (μmol/mL) |
|---|---|---|---|
| PROLI/NO | 0.16 ± 0.05 | 2.8 ± 0.1 | 5.10 ± 0.51 |
| DEA/NO | 0.31 ± 0.02 | 4.6 ± 2.3 | 9.16 ± 0.33 |
| PAPA/NO | 2.6 ± 0.4 | 43.4 ± 3.9 | 8.83 ± 0.64 |
| SPER/NO | 45.3 ± 4.6 | 168.2 ± 17.0 | 7.73 ± 0.71 |
a
Half-life of NO release.
b
Duration of NO release.
c
Total amount of NO released normalized to the injected volume from the liposome stock solution. Respective pH 7.4 half-lives of free (i.e., unencapsulated) PROLI/NO, DEA/NO, PAPA/NO, SPER/NO at 37 °C : 2 s, 2 min, 15 min, and 37 min.