Table 1.
Laboratory measurements
| Day 11 | Day 12 | Day 14 | Day 16 | Day 17 | Day 18 (death) | Normal range | |
|---|---|---|---|---|---|---|---|
| Blood count | |||||||
| Leucocyte count (cells×109 per L) | 4·7 | 3·8 | 7·2 | 7·6 | 6·7 | 4·8 | 3·5–9·8 |
| Lymphocytes (proportion of 1·0) | ND | 0·08 | ND | ND | ND | 0·05 | 0·16–0·45 |
| Platelet count (cells×109 per L) | 36 | 18 | 11 | <5 | 8 | <5 | 140–360 |
| Haematocrit (proportion of 1·0) | 0·299 | 0·310 | 0·219 | 0·246 | 0·265 | 0·152 | 0·40–0·53 |
| Haemoglobin (g/L) | 100 | 103 | 74 | 85 | 92 | 51 | 135–175 |
| Coagulation variables | |||||||
| Prothrombin time (international normalised ratio) | 1·3 | 1·4 | 1·5 | 1·5 | 1·7 | 2·5 | .. |
| Partial thromboplastin time (s) | 46 | 50 | 57 | 40 | 46 | 58 | 26–37 |
| Serological variables | |||||||
| Creatine kinase (μkat/L) | 2·4 | ND | ND | 13·8 | 28·1 | 26·5 | 0·5–3·4 |
| C-reactive protein (nmol/L) | 652·4 | 800·9 | 2247·7 | 473·3 | 285·7 | 167·6 | <47·6 |
| Procalcitonin (μg/L) | 0·24 | ND | ND | ND | 1·01 | 1·61 | <0·5 |
| Serum creatinine (μmol/L) | 70·7 | 70·7 | 221·0 | 194·5 | 247·5 | 327·1 | 61·9–106·1 |
| Urea (mmol/L) | 15·3 | 18·3 | 39·8 | 25·3 | 34·6 | 38·5 | 3·0–9·0 |
| Lactate dehydrogenase (μkat/L) | 9·5 | 9·2 | ND | ND | 21·9 | 34·8 | 2·0–3·7 |
| Gamma-glutamyltransferase (U/L) | 47 | ND | 57 | 40 | ND | 27 | 12–64 |
| Alanine transaminase (μkat/L) | 0·48 | ND | 0·45 | 0·40 | ND | 1·80 | <0·75 |
| Total bilirubin (μmol/L) | 5·3 | ND | 20·5 | 17·1 | ND | 18·8 | 3·4–20·5 |
ND=not determined.