Table 2.
Molecular analysis of the A/Taiwan/2/2013 H6N1 virus by position
| Substitutions | A/Taiwan/2/2013 | Function | ||
|---|---|---|---|---|
| PB2 | ||||
| 627 | E* | K† | E | Replication ability |
| 701 | D* | Q† | D | Nuclear import |
| PB1-F2 | ||||
| 66 | N* | S† | Truncated form (57/90 aminoacids) | Induction of apoptosis |
| Haemagglutinin | ||||
| Cleavage site | Single basic aminoacid | Multiple basic aminoacids | Single basic aminoacid (PQIATR/G) | Haemagglutinin cleavage |
| 226 | Q‡ | L§ | Q | Increased virus binding to α2-6 sialic acid receptor |
| 228 | G‡ | S§ | S | Increased virus binding to α2-6 sialic acid receptor |
| Neuraminidase | ||||
| 275 | H¶ | Y‖ | H | Oseltamivir resistance |
| 41–52 and 68–69 | .. | .. | Deleted | Unknown |
| M2 | ||||
| 31 | S¶ | N‖ | N | Adamantane resistance |
| NS1 | ||||
| 92 | D | E | D | Unknown |
| C-terminus | RSEV | ESEV | EPEV | PDZ ligand domain |
*
Low pathogenicity.
†
High pathogenicity.
‡
Avian receptor specificity.
§
Human receptor specificity.
¶
Antiviral susceptible.
‖
Antiviral resistant.