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. 2020 Apr 17;6(16):eaaz4316. doi: 10.1126/sciadv.aaz4316

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 2 — (A) Schematic illustration showing different types of cell-SNC interactions. (B) The uptake of the softest and the stiffest SNCs by RAW264.7 and SKOV3 cells; inset is the magnified graph of the first two groups. (C) The cellular uptake and binding of SNCs were measured at 4° and 37°C, respectively. (D) Four-hour cellular uptake and binding of FA-PEG–modified SNCs in RAW264.7 and (E) SKOV3 cells; values are compared to the SNCs having the highest Young’s modulus. (F) Four-, 12-, and 24-hour cellular uptake of FA-PEG–modified SNCs in RAW264.7 and (G) SKOV3 cells; at every time point, values are compared to the SNCs having the highest Young’s modulus. All values are means ± SD (n = 3, with *P < 0.05, **P < 0.01, and #P < 0.001; N.S., not significant).