Table 5. Studies that have applied FRESCO for stabilization of enzymes, to date.

Enzyme	Abbreviation	Size (aa)	Quaternary structure	ΔTm	Reference
Limonene epoxide hydrolase	LEH	149	Dimer	+35 °C	(Wijma et al., 2014)
Haloalkane dehalogenase	LinB	250	Monomer	+22 °C	(Floor et al., 2014)
Hydroxymethyl furfural oxidase	HMFO	525	Monomer	+12 °C	(Martin et al., 2018)
Peptide amidase	PAM	508	Monomer	+23 °C	(Wu et al., 2016)
Halohydrin dehalogenase	HheC	254	Tetramer	+28 °C	(Arabnejad et al., 2017)
Cyclohexanone monooxygenase	CHMO	529	Monomer	+13 °C	(Fürst et al., 2019)
Glucose oxidase	GOX	605	Dimer	+8.5 °C	(Mu et al., 2019)
ω-Transaminase	ω-TA	455	Dimer	+23 °C	(Meng et al., 2020)
Short-chain dehydrogenase	ADHA	246	Tetramer	+45 °C	This work