Table 1:
Demographic and clinical characteristics collected at enrollment according to new exposure category (GA exposure after enrollment)*
| Demographics and Comorbidities | No new exposure (N=1,283) | GA without N2O (N=280) | GA with N2O (N=256) | |||
|---|---|---|---|---|---|---|
| Age (y)‡ | 79.3 | (5.2) | 78.4 | (4.6) | 77.3 | (4.9) |
| Sex† | ||||||
| Male | 651 | (51%) | 160 | (57%) | 133 | (52%) |
| Female | 632 | (49%) | 120 | (43%) | 123 | (48%) |
| Education | ||||||
| Less than 12 years | 119 | (9%) | 20 | (7%) | 28 | (11%) |
| 12 years | 438 | (34%) | 92 | (33%) | 81 | (32%) |
| 13–15 years | 319 | (25%) | 71 | (25%) | 62 | (24%) |
| 16 years and above | 407 | (32%) | 97 | (35%) | 85 | (33%) |
| Smoking status | ||||||
| Never | 692 | (54%) | 134 | (48%) | 132 | (52%) |
| Former | 543 | (42%) | 135 | (48%) | 119 | (46%) |
| Current | 48 | (4%) | 11 | (4%) | 5 | (2%) |
| Marital status | ||||||
| Single | 130 | (10%) | 23 | (8%) | 22 | (9%) |
| Married | 798 | (62%) | 195 | (70%) | 176 | (69%) |
| Widowed | 355 | (28%) | 62 | (22%) | 58 | (23%) |
| APOE-ε4 genotype (n=1816)‡ | 328 | (26%) | 72 | (26%) | 84 | (33%) |
| Ever diagnosed alcohol problem (n=1,816)‡ | 45 | (4%) | 9 | (3%) | 15 | (6%) |
| Charlson Comorbidity Index† | 3 | [2, 6] | 4 | [2, 6] | 3 | [1, 5] |
| Midlife diabetes | 75 | (6%) | 8 | (3%) | 12 | (5%) |
| Midlife hypertension | 441 | (34%) | 110 | (39%) | 95 | (37%) |
| Midlife dyslipidemia | 544 | (42%) | 137 | (49%) | 120 | (47%) |
| Atrial fibrillation | 216 | (17%) | 48 | (17%) | 30 | (12%) |
| Congestive heart failure | 127 | (10%) | 31 | (11%) | 22 | (9%) |
| Stroke† | 69 | (5%) | 18 | (6%) | 9 | (4%) |
| Coronary artery disease | 505 | (39%) | 119 | (43%) | 87 | (34%) |
| Cognitive status‡ | ||||||
| Cognitively unimapired | 1,075 | (84%) | 252 | (90%) | 237 | (93%) |
| Mild cognitive impairment | 208 | (16%) | 28 | (10%) | 19 | (7%) |
*
Values are n (%) for categorical variables, mean (SD) for age, and median [Q1, Q3] for Charlson comorbidity index. Exposure category is determined by new exposure status prior to censoring or end of follow-up. When not all data is available numbers of rows with complete information are presented.
†
Indicates a significant univariable association (P<0.05) between the given characteristic and cause-specific hazard for GA without N2O
‡
Indicates a significant univariable association (P<0.05) between the given characteristic and cause-specific hazard for GA with N2O