Table 2:

Multivariable Cox proportional hazards modelling of AAstroENC model scores adjusting for clinical and pathological variables. Predictors with significant p-values in bold.

Parameter	Dataset V1,AA (n=31)		Dataset V2,AA (n=93)
	HR (95% CI)	P Value	HR (95% CI)	P Value
AAstroENC Score	4.62 (1.31 - 16.23)	0.017	2.58 (1.38 - 4.83)	0.0029
Age at the time of surgery	0.27 (0.091 - 0.82)	0.02	0.74 (0.32 - 1.69)	0.47
Gleason Score ≤ 6	Ref	1.00	Ref	1.00
Gleason Score = 7	1.89 (0.86 - 4.13)	0.11	0.68 (0.19 - 2.48)	0.57
Gleason Score ≥ 8	1.09 (0.42 - 2.84)	0.85	1.07 (0.31 - 3.78)	0.91
Preoperative PSA Value	2.60 (1.11 - 6.10)	0.027	1.75 (0.82 - 3.74)	0.14
Presence of SVI	3.27 (1.21 - 8.86)	0.019	2.53 (1.20 - 5.33)	0.014
Presence of ECE	0.82 (0 - infinity)	1.00	0.94 (0.23 - 3.76)	0.93
Positive Surgical Margins	0.77 (0.30 - 1.92))	0.57	1.18 (0.61 - 2.31)	0.62
Pathologic Stage pT2x	Ref	1.00	Ref	1.00
Pathologic Stage pT3x	0.62 (0 - infinity)	1.00	1.36 (0.81 - 2.28)	1