Table 2.
Association between ADHD and genes targeted by FDA-approved ADHD drugs
| Target gene | FDA approved ADHD drug | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Stimulants | Non-stimulants | |||||||||
| Gene | Chr | Start | End | Number of SNPs | p-value | Methylphenidate and derivatives | Amphetamine and derivatives | Atomoxetine | Clonidine | Guanfacine |
| ADRA1A | 8 | 26605667 | 26724790 | 469 | 0.668 | N | Y | N | Y | N |
| ADRA1B | 5 | 159343790 | 159399551 | 118 | 0.82 | N | Y | N | Y | N |
| ADRA1D | 20 | 4201329 | 4229721 | 89 | 0.499 | N | N | N | Y | N |
| ADRA2A | 10 | 112836790 | 112840658 | 5 | 0.43 | Y | Y | Y | Y | Y |
| ADRA2B | 2 | 96778707 | 96781984 | 5 | 0.399 | Y | N | N | Y | Y |
| CARTPT | 5 | 71014990 | 71016875 | 2 | 0.376 | N | Y | N | N | N |
| CHRM1 | 11 | 62676151 | 62689279 | 25 | 0.254 | N | N | Y | N | N |
| CHRM2 | 7 | 136553416 | 136705002 | 399 | 0.049 | N | N | Y | N | N |
| CYP2D6 | 22 | 42522501 | 42526908 | 29 | 0.689 | N | N | Y | N | N |
| DRD2 | 11 | 113280318 | 113346413 | 167 | 0.237 | N | N | Y | N | N |
| HRH1 | 3 | 11178779 | 11305243 | 308 | 0.505 | N | N | Y | N | N |
| HTR1B | 6 | 78171948 | 78173490 | 5 | 0.053 | N | N | Y | N | N |
| HTR1D | 1 | 23516993 | 23521222 | 9 | 0.301 | N | N | Y | N | N |
| HTR2A | 13 | 47405685 | 47471169 | 207 | 0.775 | N | N | Y | N | N |
| HTR6 | 1 | 19991780 | 20006055 | 27 | 0.026 | N | N | Y | N | N |
| HTR7 | 10 | 92500578 | 92617671 | 305 | 0.382 | N | N | Y | N | N |
| NISCH | 3 | 52489134 | 52527087 | 68 | 0.145 | N | N | N | Y | N |
| NPY1R | 4 | 164245113 | 164265984 | 48 | 0.032 | N | N | Y | N | N |
| OPRM1 | 6 | 154331631 | 154568001 | 609 | 0.217 | N | Y | N | N | N |
| SLC18A2 | 10 | 119000604 | 119038941 | 92 | 0.347 | N | Y | N | N | N |
| SLC6A2 | 16 | 55689516 | 55740104 | 154 | 0.223 | Y | Y | Y | N | Y |
| SLC6A3 | 5 | 1392909 | 1445545 | 100 | 0.836 | Y | Y | Y | N | Y |
| SLC6A4 | 17 | 28521337 | 28563020 | 65 | 0.483 | Y | N | Y | N | Y |
| TAAR1 | 6 | 132966123 | 132967142 | 3 | 0.767 | N | Y | N | N | N |
Genes reaching nominal association p-value below 0.05 are highlighted in bold.
“Y” (meaning “yes”) indicates that a gene is targeted by the drug, while “N” (meaning “no”) indicates that a gene is not targeted by the drug. “Chr” refers to the number of a chromosome where the gene of interest is located. “Start” and “End” refer to base pair location of genes of interest.