Table 3.

The druggable genes located within the three loci significantly associated with ADHD

Locus	Gene	Number of SNPs per gene	p-value	Small molecule compound	Biotherapeutic	ADME	Drug in clinical trial	FDA approved drug
Chr1	ST3GAL3	483	3.06E−12	Yes	No	No	No	No
	KDM4A	71	2.11E−11	Yes	No	No	No	No
	PTPRF	225	5.06E−10	Yes	No	No	Yes	Yes
	TIE1	30	2.01E−08	Yes	No	No	Yes	Yes
	MPL	12	4.69E−08	Yes	Yes	No	Yes	Yes
	SLC6A9	67	2.39E−07	Yes	No	No	Yes	Yes
	ARTN	10	3.27E−06	No	No	No	No	No
Chr4	MANBA	203	5.99E−08	Yes	No	No	No	No
Chr12	KCNH3	40	4.23E−06	Yes	No	No	Yes	Yes

“p-value” column indicates the strength of association between a gene and ADHD

ADME: genes involved in the absorption, distribution, metabolism, and excretion of drugs; FDA: United States of America Food and Drug Administration; SNP: single nucleotide polymorphism