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Sox2 directly binds to the miR-486–5p promoter to activate expression in GBM neurospheres. miR-486–5p regulates expression of PTEN and FoxO1 by directly binding to their respective 3’UTRs and controlling mRNA levels. miR-486–5p activation indirectly contributes to AKT and Bim dysregulation resulting in enhanced cell growth and GBM neurosphere resistance to IR.
