Table 1:
(A) MRI Data acquisition sites for the Training cohort – TCIA. (B) Patient demographics for the training and test cohort.
| A. DATA DISTRIBUTION | ||||||
|---|---|---|---|---|---|---|
| Training Cohort (n = 130) | Independent Test Cohort (n= 73) | |||||
| Site | MR Imaging | Genomics | Site | MR Imaging | Genomics | |
| TCIA | MD Anderson | 24 | 22 | Ivy GAP | 32 | 29 |
| Henry Ford Hospital | 46 | 46 | CCF | 41 | 0 | |
| UCSF | 23 | 23 | ||||
| Duke | 9 | 9 | ||||
| Emory | 9 | 9 | ||||
| Case Western Reserve | 10 | 10 | ||||
| Thomas Jefferson | 9 | 7 | ||||
| Total cases | 130 | 125 | Total cases | 73 | 29 | |
| B. PATIENT DEMOGRAPHICS | ||||||
| Clinical Parameter | Training Cohort | Test Cohort | p-value | |||
| Age (Mean, Range in years) | 57.9 (19 – 84.8) | 58.2 (26 – 77) | 0.7597 | |||
| Gender (n, %) | Female | 47 (36%) | 31 (42%) | 0.4524 | ||
| Male | 83 (64%) | 42 (58%) | ||||
| Mean Progression Free Survival (PFS, in months) | 9.5 | 10.8 | 0.3710 | |||
| Therapy class (n, %) | RT + TMZ | 98 (75%) | 73 (100%) | |||
| RT | 32 (25%) | 0 (0%) | ||||
| TMZ | 0 (0%) | 0 (0%) | ||||
| Extent of resection [ EOR ¤ ] (n, %) | Tumor resected † | 106 (81.5%) | 3 (4%) | |||
| Gross total resection (GTR) | N/A | 40 (54.7%) | ||||
| Near total resection (NTR) | N/A | 12 (16.4%) | ||||
| Sub-total resection * (STR) | 16 (12.3%) | 12 (16.4%) | ||||
| Biopsy | 8 (6%) | 1 (1.3%) | ||||
| Laser Ablation | 0 (0%) | 5 (6.8%) | ||||
| MGMT Status (n, %) | Methylated | 39 (30%) | 32 (44%) | 0.398 | ||
| Unmethylated | 32 (25%) | 37 (51%) | ||||
| Information Unavailable | 59 (45%) | 4 (5%) | ||||
| IDH Status (n, %) | Wild type | 102 (79%) | 56 (77%) | 0.1484 | ||
| Mutated | 6 (4%) | 8 (10%) | ||||
| Information Unavailable | 22 (17%) | 9 (13%) | ||||
% - percentage values have been rounded off by one decimal. P values were computed by using Student t-test for continuous variable and Fisher exact test for categorical data. Abbreviations: MGMT - O-6-Methylguanine-DNA Methyltransferase, IDH - Isocitrate dehydrogenase. EOR ¤ : Gross total resection = No evidence of enhancing tumor in post-surgery MR imaging scans, Near total resection = > 90% tumor resection, Sub-total resection = 51-90% tumor resection .
Extent of tumor resection (GTR/NTR/STR) unknown for most of the TCIA cases.
Sub-total resection status information was available for the training cohort (TCGA-GBM) only in the cases curated from Henry Ford Hospital.