Table 2:

Cox regression analysis within the training and test cohorts. Hazard ratios, concordance using clinical and radiomic features and statistical significance (via p-value) obtained from different sub-compartments (edema, necrosis, enhancing tumor) of GBM tumor habitat on Gd-T1w MRI. Cox regression analysis was implemented in a univariable setting for clinical and molecular features, and EOR (test set only). Multivariable cox regression model was implemented for the radiomic risk score as well as the combined features. Abbreviations: 95% CI – 95% Confidence Interval, C-Index – Concordance Index, MGMT - O-6-Methylguanine-DNA Methyltransferase, IDH - Isocitrate dehydrogenase, EOR – Extent of resection.

Cox Regression Analysis
	Feature		Training Cohort			Independent Test Cohort
			Hazard Ratio (95% CI)	C- Index (95% CI)	p-value	Hazard Ratio (95% CI)	C-Index (95% CI)	p-value
Univariable Analysis	Clinical features	Age	1.017 (0.99 – 1.032)	0.54 (0.46 - 0.63)	0.145	0.9789 (0.9441 – 0.9937)	0.55 ( 0.46 - 0.64)	0.015*
		Gender	1.467 (0.8481 - 2.539)	0.53 (0.45 – 0.60)	0.17	0.7263 (0.4126 - 1.278)	0.52 (0.46 – 0.59)	0.268
	Molecular features	MGMT Status	0.694 ( 0.4061 - 1.187)	0.52 (0.48 – 0.64)	0.182	0.2646 (0.1406 - 0.4982)	0.65 (0.57 - 0.72)	< 0.0001*
		IDH Status	0.9349 (0.2868 - 3.048 )	0.51 (0.46 – 0.55)	0.724	0.2471 (0.0755 - 0.808)	0.55 (0.49 – 0.60)	0.021*
	Extent of resection (EOR)		-	-	-	0.8075 (0.60 – 2.53)	0.56 (0.44 – 0.67)	0.5562
Multivariable Analysis	Radiomic risk score		4.544 (2.901 - 7.117)	0.76 (0.67 – 0.85)	< 0.0001*	2.073 (1.211 - 3.549)	0.75 (0.68 – 0.84)	0.012*
	Clinical features + Molecular features + EOR (test set only) + Radiomic risk score		-	0.81 (0.71 – 0.90)	< 0.0001*	-	0.84 (0.67 – 0.95)	0.03*