| nsp 1 & 3 |
Inhibition of IFN signaling and blocking of host innate immune response by promotion of cellular degradation and blocks translation of host’s RNA |
| nsp 2 |
Binding to prohibition protein |
| nsp3 & 5 |
Promoting cytokine expression and cleavage of viral polyprotein |
| nsp 4 & 6 |
Contribute to structure of DMVs as transmembrane scaffold protein (DMVs formation) |
| nsp 7/8 complex |
Processivity clamp for RNA polymerase by arms hexadecameric complex |
| nsp9 |
RNA binding protein phosphatase |
| nsp 10, 16 & 14 |
Stimulation of ExoN and 2-O-MT activity |
| nsp 12 |
Replication enzyme (RNA-dependent RNA polymerase) |
| nsp 13 |
RNA helicase, 5′ triphosphatase |
| nsp 14 |
Proofreading of viral genome |
| nsp 15 |
Viral endoribonuclease and chymotrypsin-like protease |
| nsp 16 |
Avoiding MDA5 recognition and inhibit innate immunity regulation |
