Table 4.
Clinical events occurred during follow-up in the investigated patients
| Negative D-dimer | Positive D-dimer, without anticoagulation | Positive D-dimer, with anticoagulation | ||||
|---|---|---|---|---|---|---|
| Male n = 146 |
Female n = 141 |
Male n = 44 |
Female n = 15 |
Male n = 82 |
Female n = 47 |
|
| Duration of follow-up (years) | 234 | 241 | 68 | 26 | 133 | 81 |
| VTE recurrences during follow-up, n (%; 95% CI) (in women with HCT-associated index event) | 4 (2.7; 0.8–7.1) | 1 (0.7; 0–4.3) (1/89) | 5 (11.4; 4.5–24.4) | 3 (20.0; 6.3–46.0) (1/11) | 1 (1.2; 0–7.2) | 0 (0/20) |
| Incidence per 100 pt-y, % (95% CI) | 1.7 (0.5–4.5) | 0.4 (0–2.5) | 7.3 (2.8–16.5) | 11.5 (3.2–29.8) | ||
| Type of event, n | ||||||
| DVT | 3 | 1 | 5 | 1 | 0 | 0 |
| PE | 1 | 0 | 0 | 1 | 1 | 0 |
| DVT + PE | 0 | 0 | 0 | 1 | 0 | 0 |
| Other outcomes, n | ||||||
| Deatha | 0 | 0 | 0 | 0 | 0 | 0 |
| Isolated distal DVT | 2 | 1 | 2 | 0 | 0 | 0 |
| SVT | 4 | 1 | 1 | 0 | 1 | 0 |
| Arterial vascular event | 1 | 0 | 0 | 0 | 0 | 0 |
| Major bleeding, n (%; (95% CI) | 0 | 0 | 0 | 0 | 2 (2.4; 0.1–9.0) | 1 (2.1; 0–12.1) |
| Incidence per 100 pt-y (95% CI) | 1.5 (0–5.7) | 1.2 (0–7.3) | ||||
DVT proximal deep vein thrombosis, PE pulmonary embolism, SVT superficial vein thrombosis
aNo death could be attributed to thrombotic event