Table 2.
The comparisons of laboratory investigations, inflammatory and nutritional markers between pre-NACT and post-NACT
| Markers | Pre-NACT | Post-NACT | P |
|---|---|---|---|
| Laboratory investigations | |||
| Hgb (g/L) | 130.8 (± 23.8) | 126.4 (± 21.8) | < 0.001 |
| Neut (× 109/L) | 3.80 (± 1.50) | 3.08 (± 1.17) | < 0.001 |
| Lym (× 109/L) | 1.67 (± 0.55) | 1.64 (± 0.53) | 0.308 |
| Mon (× 109/L) | 0.37 (± 0.12) | 0.39 (± 0.13) | 0.011 |
| Plt (× 109/L) | 249.2 (± 81.7) | 196.5 (± 62.8) | < 0.001 |
| Inflammatory markers | |||
| NLR | 2.57 (± 1.64) | 2.08 (± 1.23) | < 0.001 |
| PLR | 165.35 (± 81.32) | 129.46 (± 51.72) | < 0.001 |
| LMR | 4.87 (± 1.84) | 4.52 (± 1.68) | 0.002 |
| SII | 652.79 (± 517.65) | 404.00 (± 239.48) | < 0.001 |
| CRPa (mg/L) | 3.00 (± 7.97) | 3.83 (± 10.71) | 0.471 |
| CARa | 0.074 (± 0.205) | 0.088 (± 0.230) | 0.616 |
| mGPSa | 1.000 | ||
| 0 | 126 (94.0) | 126 (94.0) | |
| 1 | 8 (6.0) | 8 (6.0) | |
| PIa | 1.000 | ||
| 0 | 125 (93.3) | 126 (94.0) | |
| 1 | 9 (6.7) | 8 (6.0) | |
| Nutritional markers | |||
| Alb (g/L) | 42.65 (± 3.92) | 42.64 (± 3.80) | 0.963 |
| BMI (kg/m2) | 23.39 (± 3.40) | 23.71 (± 3.21) | < 0.001 |
| PNI | 51.01 (± 5.16) | 50.83 (± 4.79) | 0.570 |
| mSIS | 0.335 | ||
| 0 | 174 (77.3) | 169 (75.1) | |
| 1 | 30 (13.3) | 35 (15.6) | |
| 2 | 21 (9.3) | 21 (9.3) | |
P values are marked in bold if less than 0.05
Alb, albumin; BMI, body mass index; CAR, C-reactive protein–albumin ratio; CRP, C-reactive protein; GPS, glasgow prognostic score; Hgb, hemoglobin; LMR, lymphocyte-to-monocyte ratio; Lym, lymphocyte count; mGPS, modified glasgow prognostic score; Mon, monocyte count; mSIS, modified systemic inflammation score; NACT, neoadjuvant chemotherapy; Neut, neutrophil count; NLR, neutrophil-to-lymphocyte ratio; PI, prognostic index; PLR, platelet-to-lymphocyte ratio; Plt, platelet count; PNI, prognostic nutrition index; SII, systemic immune-inflammation index
aData from 134 paired patients