. 2020 Feb 18;23(3):540–549. doi: 10.1007/s10120-019-01027-6

Table 3.

The univariate analysis of inflammatory and nutritional markers

Situation	Only pre-NACT markers			Only post-NACT markers			Both pre-NACT and post-NACT markers
Situation	Pre-NACT			Post-NACT			Pre-NACT			Post-NACT			Change value^b
Adjustment	Age, sex, location, clinical stage			Age, sex, location, post-NACT clinical stage			Age, sex, location, clinical stage
Survival	OS			Post-NACT OS
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
NLR	1.128	0.973 ~ 1.308	0.059	1.008	0.782 ~ 1.264	0.994	1.127	0.972 ~ 1.308	0.068	1.011	0.803 ~ 1.272	0.927	0.893	0.489 ~ 1.630	0.711
PLR	1.002	0.998 ~ 1.005	0.343	1.003	0.997 ~ 1.009	0.330	1.001	0.998 ~ 1.005	0.387	1.003	0.997 ~ 1.010	0.273	0.874	0.459 ~ 1.661	0.680
LMR	0.936	0.801 ~ 1.094	0.408	1.141	0.966 ~ 1.347	0.121	0.934	0.800 ~ 1.091	0.391	1.162	0.980 ~ 1.378	0.084	1.202	1.029 ~ 1.405	0.020
SII	1.000	1.000 ~ 1.001	0.078	1.000	0.999 ~ 1.002	0.390	1.000	1.000 ~ 1.001	0.100	1.001	1.000 ~ 1.002	0.275	0.948	0.479 ~ 1.876	0.878
CRP^a	0.961	0.854 ~ 1.080	0.497	0.991	0.951 ~ 1.032	0.658	0.962	0.858 ~ 1.079	0.513	0.991	0.950 ~ 1.033	0.672	1.012	0.983 ~ 1.041	0.430
CAR^a	0.254	0.004 ~ 18.29	0.530	0.631	0.116 ~ 3.428	0.594	0.278	0.004 ~ 18.26	0.549	0.624	0.109 ~ 3.581	0.596	1.773	0.472 ~ 6.657	0.396
mGPS^a
0	Ref			Ref			Ref			Ref			NA	NA	NA
1	0.231	0.017 ~ 3.061	0.266	0.795	0.176 ~ 3.586	0.765	0.262	0.022 ~ 3.116	0.289	0.793	0.177 ~ 3.548	0.762	NA	NA	NA
PI^a
0	Ref			Ref			Ref			Ref			NA	NA	NA
1	0.692	0.121 ~ 3.958	0.679	0.654	0.147 ~ 2.907	0.577	0.727	0.132 ~ 4.006	0.714	0.646	0.146 ~ 2.854	0.564	NA	NA	NA
mSIS
0	Ref			Ref			Ref			Ref			NA	NA	NA
1	0.819	0.332 ~ 2.021	0.665	0.900	0.409 ~ 1.982	0.794	0.789	0.320 ~ 1.948	0.608	0.986	0.451 ~ 2.158	0.972	NA	NA	NA
2	1.009	0.391 ~ 2.605	0.984	1.692	0.731 ~ 3.923	0.220	0.966	0.374 ~ 2.500	0.943	1.692	0.726 ~ 3.942	0.223	NA	NA	NA
Hgb	0.991	0.978 ~ 1.003	0.151	0.982	0.968 ~ 0.997	0.015	0.990	0.978 ~ 1.003	0.138	0.982	0.968 ~ 0.996	0.014	0.990	0.973 ~ 1.008	0.286
Alb	0.980	0.910 ~ 1.055	0.595	0.997	0.923 ~ 1.077	0.659	0.980	0.910 ~ 1.054	0.581	0.977	0.906 ~ 1.053	0.542	0.998	0.932 ~ 1.069	0.965
BMI	1.010	0.930 ~ 1.100	0.811	0.982	0.892 ~ 1.079	0.700	1.012	0.931 ~ 1.100	0.776	0.989	0.902 ~ 1.084	0.816	0.839	0.659 ~ 1.067	0.152
PNI	0.971	0.918 ~ 1.027	0.300	1.008	0.946 ~ 1.074	0.805	0.971	0.918 ~ 1.026	0.291	1.006	0.943 ~ 1.073	0.858	1.194	0.679 ~ 2.098	0.538

P values are marked in bold if less than 0.1

Alb, albumin; BMI, body mass index; CAR, C-reactive protein–albumin ratio; CI, confidence interval; CRP, C-reactive protein; Hgb, hemoglobin; HR, hazard ratio; LMR, lymphocyte-to-monocyte ratio; mGPS, modified glasgow prognostic score; mSIS, modified systemic inflammation score; NACT, neoadjuvant chemotherapy; NA, not applicable; NLR, neutrophil-to-lymphocyte ratio; OS, overall survival; PI, prognostic index; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutrition index; ref, reference; SII, systemic immune-inflammation index

^aData from 142 pre-NACT patients and 177 post-NACT patients

^bChange value was calculated by subtracting the pre-NACT value from the post-NACT value