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Irisin activates Akt and ERK1/2 signaling and upregulates IGF-1 expression. Representative immunoblot of dose-dependent (A) and time-dependent (B) effect of irisin treatment on phosphorylation of Akt and ERK1/2 and IGF-1 expression in differentiated C2C12 myotubes. C and D Densitometric quantification of results in panels A and B, respectively. GAPDH was the loading control. Bars represent the mean ± SEM of three separate experiments (n = 3). *p < 0.05 vs. without irisin treatment
