Table 1.
Univariate and multivariate Cox regression analysis of overall survival in diffuse type gastric cancer (combined with ACRG and SMC cohorts)
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| n | HR (95% CI) | P value | n | HR (95% CI) | P value | |
| Age | 402 | 1.01 (1–1.03) | 0.04 | 402 | 1.02 (1.01–1.03) | 0.003 |
| Gender (male or female) | 402 | 1.07 (0.81–1.43) | 0.625 | |||
| AJCC stage (I, II, III or IV) | 402 | 2.52 (2.09–3.03) | 3.22 × 10–22 | 2.67 (2.2–3.23) | 1.04 × 10–23 | |
| Tumor site (cardia, body, antrum or whole) | 402 | 0.99 (0.78–1.25) | 0.9 | |||
| COD-signature (INT or CODa) | 402 | 1.68 (1.26–2.23) | 4.4 × 10–4 | 2.06 (1.53–2.77) | 1.76 × 10–6 | |
ACRG Asian Cancer Research Group, SMC Samsung Medical Center, HR hazard ratio, CI confidence interval, INT intestinal-like, COD core diffuse type
aPredicted outcome in Fig. 2 was used for analysis (INT or COD subtypes)