Fig. 8. JQ1 induced NLRP3 expression and attenuated NF-κB signaling in vivo.

a Phosphorylated NF-κB and NF-κB protein levels in RCC xenografted tumors were measured by western blotting. Data from three independent assays were quantified. b Western blot analysis of phosphorylated IκBα and IκBα protein levels in the indicated groups were determined and quantified. c The expression of NLRP3 was determined by western blotting. *P < 0.05 vs. vehicle; ^#P < 0.05 vs. JQ1.