Fig. 3. ABT-263 impairs tumor growth in vivo.

a Mel270 and b OMM1 uveal melanoma cells were subcutaneously engrafted into athymic nude mice (n = 8 per group). Once the tumours reached 100mm3, mice were treated daily with ABT- 263. The red arrow indicates the start of the treatment. The growth tumor curves were determined by measuring the tumor volume using the equation V = (L × W × W)/2, where V is tumor volume, W is tumor width, L is tumor length. Results are presented as mean (±SEM) tumor volumes (mm3). **P-value < 0.01, ***P-value < 0.001 are from 2-way anova test in ABT-263 treated versus vehicle at each point. c, d The weight of the sub-cutaneous tumor from control (Ct) and ABT-263-treated mice is shown. *P-value < 0.05, **P-value < 0.01.