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. 2020 Apr 17;6:22. doi: 10.1038/s41420-020-0259-2

Fig. 4. ABT-263 induces ER stress and activation of the unfolded protein response.

Fig. 4

a Western blot of ER stress molecules in uveal melanoma cells treated with ABT-263 5 μM for 24 h and 48 h. HSP90 is used as a loading control. Representative western blots are shown. b XBP1 splicing in uveal melanoma cells exposed to ABT-263 5 μM for 15 h. *P-value < 0.05, **P-value < 0.01. c Kinetic analysis of ER stress proteins in Mel270 cells treated with ABT-263 5 μM in the absence or presence of qVD-OPh 20 μM. HSP90 is used as a loading control. Representative western blots are shown.