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. 2020 Apr 17;11(4):245. doi: 10.1038/s41419-020-2439-7

Fig. 6. A schematic illustration of the hnRNP A0 function.

Fig. 6

Phospho-hnRNP A0 rather than non-phospho-hnRNP A0 works dominantly and stabilizes tumor-related RAB3GAP1 mRNA in cancer cells. RAB3GAP1 inactivates Rab3. ZWINT-1 facilitates chromosomal alignment in cancer cells, resulting in tumor cell progression. When hnRNP A0 is dephosphorylated in cancer cells, Rab3 is activated, thereby inducing the proteasomal degradation of ZWINT-1. This results in chromosomal misalignment, subsequently leading to the apoptosis of cancer cells.