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. 2020 Apr 8;26:e923411-1–e923411-10. doi: 10.12659/MSM.923411

Figure 3.

Figure 3

JQ1 restrained the glycolysis of B-ALL cell lines by downregulating the expression of metabolic enzymes. (A) Heatmap of glycolysis-related genes analyzed by RNA-seq in NALM6 cells after treatment with DMSO or JQ1 (1 μM) for 48 h. (B–D) Relative mRNA expression levels of HK2, PKM2, and LDHA measured by qRT-PCR in NALM6, REH, SEM, and RS411 cells after treatment with DMSO or JQ1 (1 μM) for 48 h. (E) Protein expressions of HK2, PFKP, PKM2, and LDHA detected by Western blot in NALM6, REH, SEM, and RS411 cells after DMSO or JQ1 (1 μM) treatment for 48 h.* P<0.05; ** P<0.01.