Figure 4.

Results of pain threshold measurement in each group of mice at each time point. Four weeks after hUC-MSC transplantation (5 weeks after SCI), mice in each group were tested every two weeks (5, 7, and 9 weeks after SCI). The von Frey wire was used to vertically stimulate the skin surface under the foot of the hind paw, and the pressure (g) at which paw withdrawal occurred was recorded. The median value was measured four times at 2 min intervals to get the pain threshold (g). For the same time point, the pain threshold of the hUC-MSC treatment group was significantly higher than that of the model group (P < 0.01; n = 8/group). Data are expressed as the mean ± SD, and repeated measures analysis of variance (ANOVA) and Tukey's one-way analysis of variance for post hoc testing were used. ^∗∗P < 0.01.